Description
Product Characteristics:
Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol. Facilitates cellular uptake of long-chain free fatty acids.
Subcellular location: Cytoplasm, Cell membrane
Synonyms: ASPATA, FABP pm, Got 2, Aspartate aminotransferase, Aspartate aminotransferase 2, Aspartate aminotransferase, mitochondrial, EC 2.6.1.1, FABP 1, FABPpm, Fatty acid binding protein, FLJ40994, Glutamate oxaloacetate transaminase 2, Glutamate oxaloacetate transaminase 2, mitochondrial, Glutamate oxaloacetate transaminase, mitochondrial, Glutamic oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2), KAT4, KATIV, Kynurenine aminotransferase IV, mAspAT, mitAAT, Mitochondrial aspartate aminotransferase, OTTMUSP00000017748, Plasma membrane fatty acid binding protein, Plasma membrane-associated fatty acid-binding protein, Transaminase A, MGC102129, MGC115763, AL022787, AATM_HUMAN.
Target Information: This gene encodes a membrane transporter that exports free sialic acids that have been cleaved off of cell surface lipids and proteins from lysosomes. Mutations in this gene cause sialic acid storage diseases, including infantile sialic acid storage disorder and and Salla disease, an adult form. [provided by RefSeq, Jul 2008]